A Breakthrough Innovation in Immune-Nutrition
SPMs are lipid mediators essential to promoting resolution of the inflammatory process and a return to homeostasis (body’s equilibrium) 1*.
How Lipinova SPMs work
SPMs are natural metabolites obtained through a conversion from EPA and DHA.
They are bioactive mediators that target resolution of the inflammatory response by activating or inhibiting specific cellular receptors, therefore assisting the immune system’s natural response1*.
Unlike conventional treatments, SPMs do not block inflammation, instead they support the body’s ability to naturally terminate the inflammation process1*.
How Lipinova SPMs are Obtained
The foundation for Lipinova is the unique combination of fractionation and purification techniques applied to Omega-3 rich oil. The SPM content is standardized to 18-HEPE, 17-HDHA, 14-HDHA.
Lipinova SPMs are the result of extensive research and development in conjunction with leading specialists and universities.
- Supplementation with SPMs improves the body’s natural capacity to resolve inflammation*
- SPMs do not suppress the body’s natural immune response1
- Effectiveness demonstrated through clinical evidence
- Unique and IP protected2
- Non-GMO and gluten-free
- Shelf life: 24 months
The Inflammatory Response
Inflammation is a natural and protective reaction in response to tissue damage, cellular injury, pathogen invasion or irritants.
The goal of inflammation is to recruit phagocytes and plasma proteins to the injured or invaded area in order to:
- Isolate, destroy or inactivate invaders (phagocytosis)
- Remove cell debris and clean the area (efferocytosis)
- Prepare the subsequent healing and repair
Inflammation is a self-limited process that enables healing and a return to homeostasis.

SPMs Play an Active Role in the Inflammatory Process
- Resolution of inflammation is an ACTIVE process, necessary for healing.
- Without resolution, prolonged acute inflammation can become chronic and provoke tissue damage, organ fibrosis and loss of function.
Chronic inflammation is the underlying cause of a wide range of diseases and conditions such as obesity, metabolic syndrome, cardiovascular disease and diabetes.
1.Buckley, C.D., Gilroy, D.W., Serhan, C.N. Proresolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammation. Immunity. 2014 Mar; 40(3): 315-27. doi: 10.1016/j.immuni.2014.02.009
2.Patented in Australia/AU 2013259503; Japan/JP 6370775; New Zealand/NZ 702325. Patent Pending in USA and EU.
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